Title : Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways.

Pub. Date : 2019 Dec

PMID : 30873870






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Moreover, after pretreatment with N-acetyl-cysteine, Shikonin increased the production of reactive oxygen species that are involved in regulating ER stress-mediated apoptosis and p38-activated autophagy, as evidenced by the reversion of cell viability and apoptosis and a decrease in p-eIF2alpha, CHOP, p-p38, LC3B-II, and Beclin 1 levels. shikonin microtubule associated protein 1 light chain 3 beta Homo sapiens