Pub. Date : 2016 Apr 15
PMID : 30873458
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | At 3 mths, there were more dysplastic hepatocytes in DEN-injected foz/foz than Wt, with increased liver injury (serum ALT), hepatocyte apoptosis (M30-positive cells) and proliferation (cyclin D1, cyclin E, PCNA), but neither NF-kappaB nor STAT3 activation. | Diethylnitrosamine | signal transducer and activator of transcription 3 | Mus musculus |
| 2 | Conclusions: Accelerated DEN-induced HCC in obese/diabetic mice is linked to enhanced growth of dysplastic hepatocytes that cannot be attributed to NF-kappaB or IL-6/STAT3 activation, nor to sustained mTORC1 activation. | Diethylnitrosamine | signal transducer and activator of transcription 3 | Mus musculus |