Pub. Date : 2019
PMID : 30863781
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pioglitazone Ameliorates Atorvastatin-Induced Islet Cell Dysfunction through Activation of FFA1 in INS-1 Cells. | Atorvastatin | free fatty acid receptor 1 | Rattus norvegicus |
| 2 | In this study, we found that atorvastatin decreased potassium-stimulated insulin secretion and inhibited the expression of FFA1, PDX-1, and BETA2/NeuroD in INS-1 cells. | Atorvastatin | free fatty acid receptor 1 | Rattus norvegicus |
| 3 | Further study demonstrated that pioglitazone prevented the impairment of insulin secretion induced by atorvastatin and enhanced the expression of FFA1, PDX-1, and BETA2/NeuroD reduced by atorvastatin in INS-1 cells. | Atorvastatin | free fatty acid receptor 1 | Rattus norvegicus |
| 4 | In addition, the preventive effect of pioglitazone on atorvastatin-induced impairment of insulin secretion and the enhancement of the expression of PDX-1 and BETA2/NeuroD was abolished by knockdown of FFA1 using siRNA or the PLC inhibitor, U-73122, respectively. | Atorvastatin | free fatty acid receptor 1 | Rattus norvegicus |