PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30863781-0 2019 Pioglitazone Ameliorates Atorvastatin-Induced Islet Cell Dysfunction through Activation of FFA1 in INS-1 Cells. Atorvastatin 25-37 free fatty acid receptor 1 Rattus norvegicus 91-95 30863781-3 2019 In this study, we found that atorvastatin decreased potassium-stimulated insulin secretion and inhibited the expression of FFA1, PDX-1, and BETA2/NeuroD in INS-1 cells. Atorvastatin 29-41 free fatty acid receptor 1 Rattus norvegicus 123-127 30863781-4 2019 Further study demonstrated that pioglitazone prevented the impairment of insulin secretion induced by atorvastatin and enhanced the expression of FFA1, PDX-1, and BETA2/NeuroD reduced by atorvastatin in INS-1 cells. Atorvastatin 187-199 free fatty acid receptor 1 Rattus norvegicus 146-150 30863781-5 2019 In addition, the preventive effect of pioglitazone on atorvastatin-induced impairment of insulin secretion and the enhancement of the expression of PDX-1 and BETA2/NeuroD was abolished by knockdown of FFA1 using siRNA or the PLC inhibitor, U-73122, respectively. Atorvastatin 54-66 free fatty acid receptor 1 Rattus norvegicus 201-205