Title : Drug library screen reveals benzimidazole derivatives as selective cytotoxic agents for KRAS-mutant lung cancer.

Pub. Date : 2019 Jun 1

PMID : 30862488






4 Functional Relationships(s)
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1 Drug library screen reveals benzimidazole derivatives as selective cytotoxic agents for KRAS-mutant lung cancer. benzimidazole KRAS proto-oncogene, GTPase Homo sapiens
2 The screening identified the cytotoxic effects of benzimidazole derivatives on KRAS-mutant lung cancer cells. benzimidazole KRAS proto-oncogene, GTPase Homo sapiens
3 Treatments with two benzimidazole derivatives, methiazole and fenbendazole-both of which are structurally specific-yielded significant suppression of the RAS-related signaling pathways in KRAS-mutated cells. benzimidazole KRAS proto-oncogene, GTPase Homo sapiens
4 Our study demonstrates that these benzimidazole derivatives play an important role in suppressing KRAS-mutant lung cancer cells, thus offering a novel combinatorial therapeutic approach against such cancer cells. benzimidazole KRAS proto-oncogene, GTPase Homo sapiens