Pub. Date : 2019 Jun 1
PMID : 30862488
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Drug library screen reveals benzimidazole derivatives as selective cytotoxic agents for KRAS-mutant lung cancer. | benzimidazole | KRAS proto-oncogene, GTPase | Homo sapiens |
| 2 | The screening identified the cytotoxic effects of benzimidazole derivatives on KRAS-mutant lung cancer cells. | benzimidazole | KRAS proto-oncogene, GTPase | Homo sapiens |
| 3 | Treatments with two benzimidazole derivatives, methiazole and fenbendazole-both of which are structurally specific-yielded significant suppression of the RAS-related signaling pathways in KRAS-mutated cells. | benzimidazole | KRAS proto-oncogene, GTPase | Homo sapiens |
| 4 | Our study demonstrates that these benzimidazole derivatives play an important role in suppressing KRAS-mutant lung cancer cells, thus offering a novel combinatorial therapeutic approach against such cancer cells. | benzimidazole | KRAS proto-oncogene, GTPase | Homo sapiens |