Title : Incorporation of Gene-Environment Interaction Terms Improved the Predictive Accuracy of Tacrolimus Stable Dose Algorithms in Chinese Adult Renal Transplant Recipients.

Pub. Date : 2019 Jun

PMID : 30861159






3 Functional Relationships(s)
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1 In wild-type CYP3A4 rs2242480 (TT) carriers, patients who took calcium channel blockers had lower tacrolimus stable doses than those without the concomitant medications (P < 1 x 10-4 ). Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Our finding suggested that wild-type CYP3A4 rs2242480 (TT) carriers should be more cautious to take tacrolimus when they are coadministrated with calcium channel blockers, and CYP3A5 rs776746 (AA) carriers may need higher tacrolimus dosage when they are in combination with hypertension. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 Our finding suggested that wild-type CYP3A4 rs2242480 (TT) carriers should be more cautious to take tacrolimus when they are coadministrated with calcium channel blockers, and CYP3A5 rs776746 (AA) carriers may need higher tacrolimus dosage when they are in combination with hypertension. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens