Title : Tyrosine kinase inhibitors vandetanib, lenvatinib and cabozantinib modulate oxidation of an anticancer agent ellipticine catalyzed by cytochromes P450 in vitro.

Pub. Date : 2019 Feb

PMID : 30860683






1 Functional Relationships(s)
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1 CONCLUSION: The results found demonstrate that TKIs vandetanib, lenvatinib and cabozantinib cause a decrease in oxidative activation of DNA-damaging drug ellipticine by several CYP enzymes in vitro which might lead to a decrease in its pharmacological efficiency. vandetanib cytochrome P450 family 4 subfamily F member 3 Homo sapiens