Title : Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells through suppression of EGFR/RAS/RAF/MEK/ERK signaling pathway.

Pub. Date : 2019

PMID : 30858760






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells through suppression of EGFR/RAS/RAF/MEK/ERK signaling pathway. epigallocatechin gallate epidermal growth factor receptor Homo sapiens
2 EGCG reduced the protein levels of phospho (p)-epidermal growth factor receptor (EGFR), H-RAS, p-RAF, p-MEK1/2, and p-extracellular signal-regulated protein kinase 1/2 (ERK1/2) in human thyroid carcinoma cells. epigallocatechin gallate epidermal growth factor receptor Homo sapiens
3 EGCG reduced the protein levels of phospho (p)-epidermal growth factor receptor (EGFR), H-RAS, p-RAF, p-MEK1/2, and p-extracellular signal-regulated protein kinase 1/2 (ERK1/2) in human thyroid carcinoma cells. epigallocatechin gallate epidermal growth factor receptor Homo sapiens
4 Conclusions: EGCG could reduce the growth and increase the apoptosis of human thyroid carcinoma cells through suppressing the EGFR/RAS/RAF/MEK/ERK signaling pathway. epigallocatechin gallate epidermal growth factor receptor Homo sapiens