Pub. Date : 2019 Mar 11
PMID : 30858408
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Upregulation of cochlear TRPV1 expression is related to cisplatin-mediated ototoxicity. | Cisplatin | transient receptor potential cation channel, subfamily V, member 1 | Rattus norvegicus |
| 2 | Here we report that direct TRPV1 activation by localized trans-tympanic (TT) or oral administration of capsaicin (TRPV1 agonist) prevents cisplatin ototoxicity by sustained increased activation of pro-survival transcription factor signal transducer and activator of transcription (STAT3) in the Wistar rat. | Cisplatin | transient receptor potential cation channel, subfamily V, member 1 | Rattus norvegicus |
| 3 | Here we report that direct TRPV1 activation by localized trans-tympanic (TT) or oral administration of capsaicin (TRPV1 agonist) prevents cisplatin ototoxicity by sustained increased activation of pro-survival transcription factor signal transducer and activator of transcription (STAT3) in the Wistar rat. | Cisplatin | transient receptor potential cation channel, subfamily V, member 1 | Rattus norvegicus |