Title : Attenuation of the effects of oxidative stress by the MAO-inhibiting antidepressant and carbonyl scavenger phenelzine.

Pub. Date : 2019 May 1

PMID : 30857888






1 Functional Relationships(s)
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Protein Name
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1 It inhibits gamma-aminobutyric acid (GABA) transaminase, resulting in elevated brain GABA levels, inhibits both MAO and primary amine oxidase and, due to its hydrazine-containing structure, reacts chemically to sequester a number of reactive aldehydes (e.g. acrolein and 4-hydroxy-2-nonenal) proposed to be implicated in oxidative stress in a number of neurodegenerative disorders. Acrolein 4-aminobutyrate aminotransferase Rattus norvegicus