Title : Organotin compound DBDCT induces CYP3A suppression through NF-κB-mediated repression of PXR activity.

Pub. Date : 2019 May 22

PMID : 30848264






1 Functional Relationships(s)
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1 But whether hepatic drug-metabolizing enzymes and their regulatory nuclear receptors including pregnane PXR and constitutive androstane CAR binding with retinoid receptor RXR as a heterodimer are involved in the DBDCT-mediated regulation of CYP3A remains unclear. androstane cytochrome P450 family 3 subfamily A member 4 Homo sapiens