Title : In situ hydrogelation of bicalutamide-peptide conjugates at prostate tissue for smart drug release based on pH and enzymatic activity.

Pub. Date : 2019 Mar 14

PMID : 30839985






2 Functional Relationships(s)
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Protein Name
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1 Here we report the design and syntheses of a novel class of histidine-containing hexapeptide derivatives (Nap-1 and ID-1) for in situ hydrogelation at the zinc ion-rich prostate tissue. Histidine nucleosome assembly protein 1 like 1 Homo sapiens
2 Thanks to the efficient co-ordination between zinc and histidine, both Nap-1 and ID-1 displayed excellent self-assembly capability with a high sensitivity to zinc ions at ~0.1 equivalency. Histidine nucleosome assembly protein 1 like 1 Homo sapiens