Title : Selective inhibition of monoamine oxidase type B by MDL 72145 increases the central effects of L-dopa without modifying its cardiovascular effects.

Pub. Date : 1986 Jan

PMID : 3082400






2 Functional Relationships(s)
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1 Selective inhibition of monoamine oxidase type B by MDL 72145 increases the central effects of L-dopa without modifying its cardiovascular effects. Levodopa monoamine oxidase B Rattus norvegicus
2 The potential of a new, potent, irreversible and selective inhibitor of monoamine oxidase type B, (E)-2-(3,4-dimethoxyphenyl)-3-fluorallyamine (MDL 72145), to augment the effects of L-DOPA in an animal model which reproduces the biochemical defect of Parkinson"s disease has been evaluated. Levodopa monoamine oxidase B Rattus norvegicus