Title : Kindlin Is Mechanosensitive: Force-Induced Conformational Switch Mediates Cross-Talk among Integrins.

Pub. Date : 2019 Mar 19

PMID : 30819565






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Under force, R577 on one protomer switches from interacting with S550 to forming new hydrogen bonds with E553 on the neighboring protomer, resulting in the strengthening of the kindlin2 dimer in complex with integrin beta1. Hydrogen FERM domain containing kindlin 2 Homo sapiens