Pub. Date : 2019 Apr
PMID : 30816513
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Resveratrol induces cell death through ROS-dependent downregulation of Notch1/PTEN/Akt signaling in ovarian cancer cells. | Resveratrol | AKT serine/threonine kinase 1 | Homo sapiens |
2 | Western blot analysis demonstrated that resveratrol also upregulated phospho-phosphatase and tensin homolog (p-PTEN) and downregulated phospho-Akt (p-Akt). | Resveratrol | AKT serine/threonine kinase 1 | Homo sapiens |
3 | Western blot analysis demonstrated that resveratrol also upregulated phospho-phosphatase and tensin homolog (p-PTEN) and downregulated phospho-Akt (p-Akt). | Resveratrol | AKT serine/threonine kinase 1 | Homo sapiens |
4 | Overexpression of p-Akt by transfection with a constitutively active form (caAkt), and the p-PTEN inhibitor SF1670 prevented resveratrol-induced cell death. | Resveratrol | AKT serine/threonine kinase 1 | Homo sapiens |
5 | Taken together, the results of the present study suggest that resveratrol induces caspase-dependent cell death through suppression of Notch1 and PTEN/Akt signaling and it is mediated by increased ROS generation in human ovarian cancer cells. | Resveratrol | AKT serine/threonine kinase 1 | Homo sapiens |