Title : Resveratrol induces cell death through ROS‑dependent downregulation of Notch1/PTEN/Akt signaling in ovarian cancer cells.

Pub. Date : 2019 Apr

PMID : 30816513






5 Functional Relationships(s)
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1 Resveratrol induces cell death through ROS-dependent downregulation of Notch1/PTEN/Akt signaling in ovarian cancer cells. Resveratrol AKT serine/threonine kinase 1 Homo sapiens
2 Western blot analysis demonstrated that resveratrol also upregulated phospho-phosphatase and tensin homolog (p-PTEN) and downregulated phospho-Akt (p-Akt). Resveratrol AKT serine/threonine kinase 1 Homo sapiens
3 Western blot analysis demonstrated that resveratrol also upregulated phospho-phosphatase and tensin homolog (p-PTEN) and downregulated phospho-Akt (p-Akt). Resveratrol AKT serine/threonine kinase 1 Homo sapiens
4 Overexpression of p-Akt by transfection with a constitutively active form (caAkt), and the p-PTEN inhibitor SF1670 prevented resveratrol-induced cell death. Resveratrol AKT serine/threonine kinase 1 Homo sapiens
5 Taken together, the results of the present study suggest that resveratrol induces caspase-dependent cell death through suppression of Notch1 and PTEN/Akt signaling and it is mediated by increased ROS generation in human ovarian cancer cells. Resveratrol AKT serine/threonine kinase 1 Homo sapiens