PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30816513-0 2019 Resveratrol induces cell death through ROS-dependent downregulation of Notch1/PTEN/Akt signaling in ovarian cancer cells. Resveratrol 0-11 AKT serine/threonine kinase 1 Homo sapiens 83-86 30816513-7 2019 Western blot analysis demonstrated that resveratrol also upregulated phospho-phosphatase and tensin homolog (p-PTEN) and downregulated phospho-Akt (p-Akt). Resveratrol 40-51 AKT serine/threonine kinase 1 Homo sapiens 143-146 30816513-7 2019 Western blot analysis demonstrated that resveratrol also upregulated phospho-phosphatase and tensin homolog (p-PTEN) and downregulated phospho-Akt (p-Akt). Resveratrol 40-51 AKT serine/threonine kinase 1 Homo sapiens 150-153 30816513-8 2019 Overexpression of p-Akt by transfection with a constitutively active form (caAkt), and the p-PTEN inhibitor SF1670 prevented resveratrol-induced cell death. Resveratrol 125-136 AKT serine/threonine kinase 1 Homo sapiens 20-23 30816513-10 2019 Taken together, the results of the present study suggest that resveratrol induces caspase-dependent cell death through suppression of Notch1 and PTEN/Akt signaling and it is mediated by increased ROS generation in human ovarian cancer cells. Resveratrol 62-73 AKT serine/threonine kinase 1 Homo sapiens 150-153