Title : Suppression of Akt-mTOR pathway rescued the social behavior in Cntnap2-deficient mice.

Pub. Date : 2019 Feb 28

PMID : 30816216






1 Functional Relationships(s)
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1 Dysregulation of mTOR signaling has been implicated in the pathogenesis of certain types of ASD, and inhibition of mTOR by rapamycin has been demonstrated to be an effective therapeutics for impaired social interaction in Tsc1+/-, Tsc2+/-, Pten-/- mice and valproic acid-induced ASD animal models. Sirolimus phosphatase and tensin homolog Mus musculus