Pub. Date : 2019 Oct
PMID : 30814036
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MPGES-1 derived PGE2 inhibits cell migration by regulating ARP2/3 in the pathogenesis of Hirschsprung disease. | Dinoprostone | prostaglandin E synthase | Homo sapiens |
| 2 | BACKGROUND: We previously studied the metabolomics, transcriptomics and proteomics of intestinal tissue of Hirschsprung disease (HSCR) patients; the results suggested that the expression of prostaglandin E2(PGE2), prostaglandin E receptor 2(PTGER2) and microsomal prostaglandin E synthase-1 (mPGES-1) notably increased in HSCR colon tissues. | Dinoprostone | prostaglandin E synthase | Homo sapiens |
| 3 | BACKGROUND: We previously studied the metabolomics, transcriptomics and proteomics of intestinal tissue of Hirschsprung disease (HSCR) patients; the results suggested that the expression of prostaglandin E2(PGE2), prostaglandin E receptor 2(PTGER2) and microsomal prostaglandin E synthase-1 (mPGES-1) notably increased in HSCR colon tissues. | Dinoprostone | prostaglandin E synthase | Homo sapiens |
| 4 | RESULTS: MPGES-1 derived PGE2 decreased the relative expression of EP2 and ARP2/3 and caused damage to cytoskeleton. | Dinoprostone | prostaglandin E synthase | Homo sapiens |
| 5 | CONCLUSIONS: MPGES-1 derived PGE2 inhibits the cell migration by regulating ARP2/3 complex via prostaglandin E2 receptor. | Dinoprostone | prostaglandin E synthase | Homo sapiens |