Pub. Date : 2019 Nov
PMID : 30811078
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The induction of ferroptosis by impairing STAT3/Nrf2/GPx4 signaling enhances the sensitivity of osteosarcoma cells to cisplatin. | Cisplatin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | Western blotting analysis indicated that protein levels of p-STAT3 (Ser727), nuclear factor erythroid 2-related factor 2 (Nrf2), and glutathione peroxidase 4 (GPx4) in drug-resistant strains increased significantly in response to cisplatin. | Cisplatin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | The reduction of protein levels of p-STAT3 (Ser727), Nrf2, and GPx4 in MG63/DDP and Saos-2/DDP cells resulted in increased ferroptosis and sensitivity to cisplatin. | Cisplatin | NFE2 like bZIP transcription factor 2 | Homo sapiens |