Title : NADPH oxidase-mediated induction of reactive oxygen species and extracellular matrix deposition by insulin-like growth factor binding protein-5.

Pub. Date : 2019 Apr 1

PMID : 30810066






1 Functional Relationships(s)
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1 In vitro analyses revealed that ROS production was induced by recombinant and adenoviral vector-mediated IGFBP-5 (AdBP5) in a dose- and time-dependent manner, regulated through MEK/ERK and JNK signaling, and primarily mediated by NADPH oxidase (Nox). Reactive Oxygen Species mitogen-activated protein kinase 1 Homo sapiens