Title : Pyrazoles containing thiophene, thienopyrimidine and thienotriazolopyrimidine as COX-2 selective inhibitors: Design, synthesis, in vivo anti-inflammatory activity, docking and in silico chemo-informatic studies.

Pub. Date : 2019 Apr

PMID : 30807897






1 Functional Relationships(s)
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1 Therefore, the thiophene analog 3 and the thienopyrimidine derivatives 10 and 11 are promising anti-inflammatory candidates that exert moderate selective COX-2 inhibition with acceptable physicochemical properties. Thiophenes mitochondrially encoded cytochrome c oxidase II Homo sapiens