Title : Effect of Multidrug-Resistant 1 (MDR1) and CYP3A4*1B Polymorphisms on Cyclosporine-Based Immunosuppressive Therapy in Renal Transplant Patients.

Pub. Date : 2019 Feb 25

PMID : 30799432






2 Functional Relationships(s)
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1 The aim of this study was to determine the relationship between CYP3A4*1B and MDR1 polymorphisms and dose requirements to achieve the target therapeutic range for CsA. Cyclosporine ATP binding cassette subfamily B member 1 Homo sapiens
2 In the case of MDR1 3435C>T polymorphism, we observed that patients with the CC genotype received lower doses of CsA than patients with the CT and TT genotypes. Cyclosporine ATP binding cassette subfamily B member 1 Homo sapiens