Title : Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis.

Pub. Date : 2019 Mar 18

PMID : 30793592






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Upon encounter of electrophiles, oxidants, or pro-inflammatory stimuli, the cysteine sensors in Keap1 are chemically modified, rendering Keap1 unable to target Nrf2 for degradation, and consequently leading to accumulation of the transcription factor and enhanced transcription of cytoprotective genes. Cysteine NFE2 like bZIP transcription factor 2 Homo sapiens