Title : Cholesterol content in cell membrane maintains surface levels of ErbB2 and confers a therapeutic vulnerability in ErbB2-positive breast cancer.

Pub. Date : 2019 Feb 20

PMID : 30786890






2 Functional Relationships(s)
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1 The synergistic effects of lovastatin with the ErbB2 inhibitor lapatinib were evaluated using an ErbB2-positive breast cancer xenograft mouse model. Lapatinib erb-b2 receptor tyrosine kinase 2 Mus musculus
2 Lovastatin also synergized with lapatinib to strongly suppress the in vivo growth of ErbB2-positive breast cancer xenografts. Lapatinib erb-b2 receptor tyrosine kinase 2 Mus musculus