Title : Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis.

Pub. Date : 2019 Feb

PMID : 30784208






1 Functional Relationships(s)
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1 Mechanistic studies showed PF-04895162 had low cytotoxic potential in human hepatocytes, but inhibited liver mitochondrial function and bile salt export protein (BSEP) transport. pyrazofurin ATP binding cassette subfamily B member 11 Homo sapiens