Pub. Date : 2019 Jun
PMID : 30770950
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To study the capability of the CYP17A1 inhibitor abiraterone acetate (AER) to antagonize the androgen receptor (AR) activation in human prostate cancer (PCa) cell lines. | Abiraterone Acetate | androgen receptor | Homo sapiens |
| 2 | To study the capability of the CYP17A1 inhibitor abiraterone acetate (AER) to antagonize the androgen receptor (AR) activation in human prostate cancer (PCa) cell lines. | Abiraterone Acetate | androgen receptor | Homo sapiens |
| 3 | To study the capability of the CYP17A1 inhibitor abiraterone acetate (AER) to antagonize the androgen receptor (AR) activation in human prostate cancer (PCa) cell lines. | Abiraterone Acetate | androgen receptor | Homo sapiens |
| 4 | To study the capability of the CYP17A1 inhibitor abiraterone acetate (AER) to antagonize the androgen receptor (AR) activation in human prostate cancer (PCa) cell lines. | Abiraterone Acetate | androgen receptor | Homo sapiens |
| 5 | The mechanism of AER cytotoxicity in LNCaP cells was studied, as well as the ability of AER to modulate AR gene expression. | Abiraterone Acetate | androgen receptor | Homo sapiens |
| 6 | AER bound AR in an almost identical manner to that of dihydrotestosterone (DHT). | Abiraterone Acetate | androgen receptor | Homo sapiens |
| 7 | The higher binding energy for AER in T877A-AR could explain the major cytotoxic effect observed in LNCaP cells. | Abiraterone Acetate | androgen receptor | Homo sapiens |
| 8 | Further, AER induced modification of AR target gene expression, suggesting a direct effect on AR activity. | Abiraterone Acetate | androgen receptor | Homo sapiens |
| 9 | Further, AER induced modification of AR target gene expression, suggesting a direct effect on AR activity. | Abiraterone Acetate | androgen receptor | Homo sapiens |
| 10 | AER-induced cytotoxicity on PCa cell lines seemed to be mediated by binding with AR. | Abiraterone Acetate | androgen receptor | Homo sapiens |
| 11 | The higher affinity of AER for T877A-AR may suggest a potential role of AER in the management of CRPC carrying this mutation; however, T877A-AR expressing CRPC patients developed AER resistance, probably due to the increase of progesterone. | Abiraterone Acetate | androgen receptor | Homo sapiens |