PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30770950-1	2019	To study the capability of the CYP17A1 inhibitor abiraterone acetate (AER) to antagonize the androgen receptor (AR) activation in human prostate cancer (PCa) cell lines.	Abiraterone Acetate	49-68	androgen receptor	Homo sapiens	93-110	
30770950-1	2019	To study the capability of the CYP17A1 inhibitor abiraterone acetate (AER) to antagonize the androgen receptor (AR) activation in human prostate cancer (PCa) cell lines.	Abiraterone Acetate	49-68	androgen receptor	Homo sapiens	112-114	
30770950-1	2019	To study the capability of the CYP17A1 inhibitor abiraterone acetate (AER) to antagonize the androgen receptor (AR) activation in human prostate cancer (PCa) cell lines.	Abiraterone Acetate	70-73	androgen receptor	Homo sapiens	93-110	
30770950-1	2019	To study the capability of the CYP17A1 inhibitor abiraterone acetate (AER) to antagonize the androgen receptor (AR) activation in human prostate cancer (PCa) cell lines.	Abiraterone Acetate	70-73	androgen receptor	Homo sapiens	112-114	
30770950-4	2019	The mechanism of AER cytotoxicity in LNCaP cells was studied, as well as the ability of AER to modulate AR gene expression.	Abiraterone Acetate	88-91	androgen receptor	Homo sapiens	104-106	
30770950-7	2019	AER bound AR in an almost identical manner to that of dihydrotestosterone (DHT).	Abiraterone Acetate	0-3	androgen receptor	Homo sapiens	10-12	
30770950-8	2019	The higher binding energy for AER in T877A-AR could explain the major cytotoxic effect observed in LNCaP cells.	Abiraterone Acetate	30-33	androgen receptor	Homo sapiens	43-45	
30770950-11	2019	Further, AER induced modification of AR target gene expression, suggesting a direct effect on AR activity.	Abiraterone Acetate	9-12	androgen receptor	Homo sapiens	37-39	
30770950-11	2019	Further, AER induced modification of AR target gene expression, suggesting a direct effect on AR activity.	Abiraterone Acetate	9-12	androgen receptor	Homo sapiens	94-96	
30770950-12	2019	AER-induced cytotoxicity on PCa cell lines seemed to be mediated by binding with AR.	Abiraterone Acetate	0-3	androgen receptor	Homo sapiens	81-83	
30770950-13	2019	The higher affinity of AER for T877A-AR may suggest a potential role of AER in the management of CRPC carrying this mutation; however, T877A-AR expressing CRPC patients developed AER resistance, probably due to the increase of progesterone.	Abiraterone Acetate	23-26	androgen receptor	Homo sapiens	37-39