Title : O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3.

Pub. Date : 2019 Mar 19

PMID : 30770249






1 Functional Relationships(s)
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1 Mechanistically, OGT-mediated O-GlcNAcylation of the serine-threonine kinase RIPK3 on threonine 467 (T467) prevented RIPK3-RIPK1 hetero- and RIPK3-RIPK3 homo-interaction and inhibited downstream innate immunity and necroptosis signaling. Threonine O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens