Pub. Date : 2019 Mar
PMID : 30765873
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Integrated analysis of multiple receptor tyrosine kinases identifies Axl as a therapeutic target and mediator of resistance to sorafenib in hepatocellular carcinoma. | Sorafenib | AXL receptor tyrosine kinase | Homo sapiens |
| 2 | We explored the biologic significance and preclinical efficacy of Axl inhibition as a therapeutic strategy in sorafenib-naive and resistant HCC. | Sorafenib | AXL receptor tyrosine kinase | Homo sapiens |
| 3 | METHODS: We evaluated Axl expression in sorafenib-naive and resistant (SR) clones of epithelial (HuH7) and mesenchymal origin (SKHep-1) using antibody arrays and confirmed tissue expression. | Sorafenib | AXL receptor tyrosine kinase | Homo sapiens |
| 4 | We confirmed sorafenib resistance to be associated with EMT and enhanced motility in both HuH7-SR and SKHep-1-SR cells documenting a 4-fold increase in Axl phosphorylation as an adaptive feature of chronic sorafenib treatment in SKHep-1-SR cells. | Sorafenib | AXL receptor tyrosine kinase | Homo sapiens |
| 5 | Axl inhibition reduced motility and enhanced sensitivity to sorafenib in SKHep-1SR cells. | Sorafenib | AXL receptor tyrosine kinase | Homo sapiens |
| 6 | In patients treated with sorafenib (n = 40), circulating Axl levels correlated with shorter survival. | Sorafenib | AXL receptor tyrosine kinase | Homo sapiens |
| 7 | CONCLUSIONS: Suppression of Axl-dependent signalling influences the transformed phenotype in HCC cells and contributes to adaptive resistance to sorafenib, providing a pre-clinical rationale for the development of Axl inhibitors as a measure to overcome sorafenib resistance. | Sorafenib | AXL receptor tyrosine kinase | Homo sapiens |
| 8 | CONCLUSIONS: Suppression of Axl-dependent signalling influences the transformed phenotype in HCC cells and contributes to adaptive resistance to sorafenib, providing a pre-clinical rationale for the development of Axl inhibitors as a measure to overcome sorafenib resistance. | Sorafenib | AXL receptor tyrosine kinase | Homo sapiens |
| 9 | CONCLUSIONS: Suppression of Axl-dependent signalling influences the transformed phenotype in HCC cells and contributes to adaptive resistance to sorafenib, providing a pre-clinical rationale for the development of Axl inhibitors as a measure to overcome sorafenib resistance. | Sorafenib | AXL receptor tyrosine kinase | Homo sapiens |
| 10 | CONCLUSIONS: Suppression of Axl-dependent signalling influences the transformed phenotype in HCC cells and contributes to adaptive resistance to sorafenib, providing a pre-clinical rationale for the development of Axl inhibitors as a measure to overcome sorafenib resistance. | Sorafenib | AXL receptor tyrosine kinase | Homo sapiens |