Title : Homoharringtonine potentiates the antileukemic activity of arsenic trioxide against acute myeloid leukemia cells.

Pub. Date : 2019 Mar 15

PMID : 30763586






2 Functional Relationships(s)
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1 Here, we report that the adhesion-induced resistance to ATO is related to the up-regulation of myeloid cell leukemia-1 (Mcl-1). Arsenic Trioxide MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 Homoharringtonine (HHT) can potentiate the anti-leukemia effects of ATO on adhered AML cells by suppressing Mcl-1 through glycogen synthase kinase-3beta (GSK3beta). Arsenic Trioxide MCL1 apoptosis regulator, BCL2 family member Homo sapiens