Pub. Date : 2019 Aug
PMID : 30760870
2 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | The immunomodulatory imide drug (IMiD) lenalidomide promotes myeloma cell death via Cereblon (CRBN)-dependent ubiquitylation and proteasome-dependent degradation of IKZF1 and IKZF3. | Lenalidomide | IKAROS family zinc finger 1 | Homo sapiens | ||
| 2 | Interaction with RUNX1 and RUNX3 inhibits CRBN-dependent binding, ubiquitylation, and degradation of IKZF1 and IKZF3 upon lenalidomide treatment. | Lenalidomide | IKAROS family zinc finger 1 | Homo sapiens | ||