Protein Name IKAROS family zinc finger 1
Organism Homo sapiens
Gene ID 10320
Gene Symbol


UniProt Q13422 (IKZF1_HUMAN), A0A2R8Y4D3 (A0A2R8Y4D3_HUMAN), R9R4D9 (R9R4D9_HUMAN), C9JTB0 (C9JTB0_HUMAN)
Relationships Total Number of functionally related compound(s) : 156
Total Number of Articles : 223

IKAROS family zinc finger 1

Gene Summary

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]

  • DNA-binding protein Ikaros
  • CLL-associated antigen KW-6
  • ikaros family zinc finger protein 1
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