Title : MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors.

Pub. Date : 2019 May 1

PMID : 30755442






1 Functional Relationships(s)
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1 Using two compounds currently in clinical development, idasanutlin (MDM2-specific) and ATSP-7041 (MDM2/4-dual), we show that MRT cells were more sensitive than other p53 wild-type cancer cell lines to inhibition of MDM2 alone as well as dual inhibition of MDM2/4. RG7388 transformed mouse 3T3 cell double minute 2 Mus musculus