Title : The Origin of CIMP, At Last.

Pub. Date : 2019 Feb 11

PMID : 30753821






1 Functional Relationships(s)
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1 provide compelling evidence that aging-like DNA methylation of multiple CpG islands, the CpG island methylator phenotype (CIMP), produces a cellular context that can tolerate BRAF activation avoiding senescence by dedicating 5-month culture of colon-derived organoids to epigenomic and stemness analysis. Cyclic IMP B-Raf proto-oncogene, serine/threonine kinase Homo sapiens