Pub. Date : 2019 Jun
PMID : 30748033
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration. | Guanosine Triphosphate | Rac family small GTPase 1 | Mus musculus |
| 2 | Here, we identified a mechanism mediated by the trafficking protein synaptotagmin-like 1 (SYTL1 or JFC1) that controls Rac1-GTP recycling from the uropod and promotes directional migration of neutrophils. | Guanosine Triphosphate | Rac family small GTPase 1 | Mus musculus |
| 3 | Mechanistically, we show that active Rac1 localizes at dynamic vesicles where endogenous JFC1 colocalizes with Rac1-GTP. | Guanosine Triphosphate | Rac family small GTPase 1 | Mus musculus |
| 4 | Mechanistically, we show that active Rac1 localizes at dynamic vesicles where endogenous JFC1 colocalizes with Rac1-GTP. | Guanosine Triphosphate | Rac family small GTPase 1 | Mus musculus |
| 5 | Super-resolution microscopy (STORM) analysis shows adjacent distribution of JFC1 and Rac1-GTP, which increases upon activation. | Guanosine Triphosphate | Rac family small GTPase 1 | Mus musculus |