Title : Direct activation of aryl hydrocarbon receptor by benzo[a]pyrene elicits T-helper 2-driven proinflammatory responses in a mouse model of allergic dermatitis.

Pub. Date : 2019 Jul

PMID : 30748024






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Benzo[a]pyrene (BaP) and 6-formylindolo[3,2-b]carbazole were used as selective ligands for the AhR. Benzo(a)pyrene aryl hydrocarbon receptor Homo sapiens
2 Benzo[a]pyrene (BaP) and 6-formylindolo[3,2-b]carbazole were used as selective ligands for the AhR. Benzo(a)pyrene aryl hydrocarbon receptor Homo sapiens
3 Pretreatment with BaP and/or 6-formylindolo[3,2-b]carbazole significantly induced cytokine release by activated keratinocytes and T-cell proliferation, whereas interleukin-12 production in bone marrow-derived dendritic cells was reduced by AhR activation. Benzo(a)pyrene aryl hydrocarbon receptor Homo sapiens