Pub. Date : 2019 Jun
PMID : 30741365
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Umbelliferone Ameliorates CCl4-Induced Liver Fibrosis in Rats by Upregulating PPARgamma and Attenuating Oxidative Stress, Inflammation, and TGF-beta1/Smad3 Signaling. | 7-hydroxycoumarin | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 2 | This study aimed to investigate the protective effect of UMB against carbon tetrachloride (CCl4)-induced liver fibrosis in rats. | 7-hydroxycoumarin | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 3 | Treatment with UMB significantly ameliorated liver function markers and pro-inflammatory cytokines and prevented CCl4-induced histological alterations. | 7-hydroxycoumarin | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 4 | In conclusion, our results demonstrated that UMB prevented CCl4-induced liver fibrosis by attenuating oxidative stress, inflammation, and TGF-beta1/Smad3 signaling, and upregulating PPARgamma. | 7-hydroxycoumarin | C-C motif chemokine ligand 4 | Rattus norvegicus |