Title : PPARβ/δ agonist GW501516 inhibits TNFα-induced repression of adiponectin and insulin receptor in 3T3-L1 adipocytes.

Pub. Date : 2019 Mar 19

PMID : 30739791






3 Functional Relationships(s)
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1 GW501516 treatment increased the expression of insulin receptor and inhibited TNFalpha-mediated repression of insulin receptor. GW 501516 insulin receptor Homo sapiens
2 GW501516 treatment increased the expression of insulin receptor and inhibited TNFalpha-mediated repression of insulin receptor. GW 501516 insulin receptor Homo sapiens
3 In summary, our study demonstrated that the PPARbeta/delta agonist, GW501516 reversed TNFalpha-induced decreases in adipocyte differentiation and adiponectin expression, and improved insulin sensitivity by increasing the expression of insulin receptor. GW 501516 insulin receptor Homo sapiens