Pub. Date : 2019 Mar 19
PMID : 30739789
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38. | Skatole | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | Extracellular signal-related kinase (ERK), p38 and c-Jun N-terminal kinase (JNK) are mitogen-activated protein kinases (MAPK) induced by skatole. | Skatole | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | None of them were repressed by CH223191, whereas the p38 inhibitor SB203580 promoted skatole-induced IEC death. | Skatole | mitogen-activated protein kinase 14 | Homo sapiens |
| 4 | These findings together indicated that skatole induces both AhR-dependent activation pathways and the AhR-independent activation of p38, consequently regulating the amount of IEC death. | Skatole | mitogen-activated protein kinase 14 | Homo sapiens |