Title : Chondroprotection of PPARĪ± activation by WY14643 via autophagy involving Akt and ERK in LPS-treated mouse chondrocytes and osteoarthritis model.

Pub. Date : 2019 Apr

PMID : 30729704






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1 Chondroprotection of PPARalpha activation by WY14643 via autophagy involving Akt and ERK in LPS-treated mouse chondrocytes and osteoarthritis model. pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus
2 In this study, we investigated the effect of PPARalpha activation by its agonist, WY14643, on the protein expression level of Aggrecan and ADAMTS5, and the protein expression level of autophagy biomarkers, including LC3B and P62, using Western blotting analysis in isolated mouse chondrocytes pre-treated with lipopolysaccharides (LPS, mimicking OA chondrocytes) with or without the autophagy inhibitor chloroquine diphosphate salt. pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus
3 The results indicated that PPARalpha activation by WY14643 promoted proteoglycan synthesis by autophagy enhancement in OA chondrocytes in vivo and in vitro concomitant with the elevation of Akt and ERK phosphorylation. pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus
4 Therefore, autophagy could contribute to the chondroprotection of PPARalpha activation by WY14643, with the implication that PPARalpha activation by WY14643 may be a potential approach for OA therapy. pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus
5 Therefore, autophagy could contribute to the chondroprotection of PPARalpha activation by WY14643, with the implication that PPARalpha activation by WY14643 may be a potential approach for OA therapy. pirinixic acid peroxisome proliferator activated receptor alpha Mus musculus