Title : Endogenous Neurosteroid (3α,5α)3-Hydroxypregnan-20-one Inhibits Toll-like-4 Receptor Activation and Pro-inflammatory Signaling in Macrophages and Brain.

Pub. Date : 2019 Feb 4

PMID : 30718548






1 Functional Relationships(s)
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1 In VTA, 3alpha,5alpha-THP (15 mg/kg, IP) administration reduced TRAF6 (~20%), CRF (~30%), and MCP-1 (~20%) levels, as well as TLR4 binding to GABAA receptor alpha2 subunits (~60%) and MyD88 (~40%). pirarubicin toll-like receptor 4 Mus musculus