Pub. Date : 2019 Feb 19
PMID : 30718413
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis. | Vitamin A | diacylglycerol O-acyltransferase 1 | Homo sapiens |
| 2 | DGAT1 acyltransferase activity sequesters retinol in ester form, preventing synthesis of retinoic acid, a cofactor for Treg generation. | Vitamin A | diacylglycerol O-acyltransferase 1 | Homo sapiens |
| 3 | In cultures with T cell-depleted lymphoid tissues, retinol enhanced Treg induction from DGAT1-/- but not from WT T cells. | Vitamin A | diacylglycerol O-acyltransferase 1 | Homo sapiens |
| 4 | These results demonstrate that DGAT1 suppresses retinol-dependent Treg formation and suggest its potential as a therapeutic target for autoimmune inflammation. | Vitamin A | diacylglycerol O-acyltransferase 1 | Homo sapiens |