Title : Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators.

Pub. Date : 2019 Mar 15

PMID : 30718161






1 Functional Relationships(s)
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1 Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. Urea potassium inwardly rectifying channel subfamily J member 3 Homo sapiens