Pub. Date : 2019 Mar
PMID : 30714345
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Herein, a promising strategy for effective delivery of phosphorothioated antisense oligodeoxyribonucleotide of TNF-alpha (PS-ATNF-alpha), targeting the intestinal inflammation based on the interaction of the single chain of triple helical beta-glucan (s-LNT) with poly-deoxyadenylic acid [poly(dA)], and the colon-specific degradation of chitosan-alginate (CA) hydrogel, is reported. | poly(dA) | tumor necrosis factor | Homo sapiens |
| 2 | Herein, a promising strategy for effective delivery of phosphorothioated antisense oligodeoxyribonucleotide of TNF-alpha (PS-ATNF-alpha), targeting the intestinal inflammation based on the interaction of the single chain of triple helical beta-glucan (s-LNT) with poly-deoxyadenylic acid [poly(dA)], and the colon-specific degradation of chitosan-alginate (CA) hydrogel, is reported. | poly(dA) | tumor necrosis factor | Homo sapiens |
| 3 | The target gene of PS-ATNF-alpha, with a poly(dA) tail through a disulfide bond (-SS-), interacts with s-LNT to form a rod-like nanocomposite of s-LNT/poly(dA)-SS-PS-ATNF-alpha, which significantly inhibits lipopolysaccharide (LPS)-induced TNF-alpha at the protein level by 38.2% and mRNA level by 48.9% in RAW264.7 macrophages. | poly(dA) | tumor necrosis factor | Homo sapiens |