Title : Dissociation mechanism of GDP from Cdc42 via DOCK9 revealed by molecular dynamics simulations.

Pub. Date : 2019 Jun

PMID : 30714195






2 Functional Relationships(s)
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1 Simulation results show that Mg2+ ion has a remarkable influence on the conformational change of switch I of Cdc42 through residue Pro34 which functions as a "clasp" to control the flexibility of switch I. magnesium ion cell division cycle 42 Homo sapiens
2 In the GDP dissociation process, the Mg2+ ion leave first to result in a suitable conformation of Cdc42 for following DOCK9 binding to. magnesium ion cell division cycle 42 Homo sapiens