PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30710424-0	2019	Metformin and tenovin-6 synergistically induces apoptosis through LKB1-independent SIRT1 down-regulation in non-small cell lung cancer cells.	Metformin	0-9	serine/threonine kinase 11	Homo sapiens	66-70	
30710424-7	2019	Metformin in combination with tenovin-6 was found to be more effective in inhibiting cell growth than either agent alone in NSCLC cell lines with different liver kinase B1 (LKB1) status.	Metformin	0-9	serine/threonine kinase 11	Homo sapiens	156-171	
30710424-7	2019	Metformin in combination with tenovin-6 was found to be more effective in inhibiting cell growth than either agent alone in NSCLC cell lines with different liver kinase B1 (LKB1) status.	Metformin	0-9	serine/threonine kinase 11	Homo sapiens	173-177	
30710424-9	2019	The marked reduction in SIRT1 expression by combination of metformin and tenovin-6 increased acetylation of p53 at lysine 382 and enhanced p53 stability in LKB1-deficient A549 cells.	Metformin	59-68	serine/threonine kinase 11	Homo sapiens	156-160	
30710424-12	2019	The study concluded that metformin with tenovin-6 may enhance antitumour effects through LKB1-independent SIRT1 down-regulation in NSCLC cells.	Metformin	25-34	serine/threonine kinase 11	Homo sapiens	89-93