Pub. Date : 2019 Mar 15
PMID : 30710045
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glycine Exhibits Neuroprotective Effects in Ischemic Stroke in Rats through the Inhibition of M1 Microglial Polarization via the NF-kappaB p65/Hif-1alpha Signaling Pathway. | Glycine | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |
| 2 | We show that glycine suppresses Hif-1alpha by inhibiting the upregulation of NF-kappaB p65 after ischemia-reperfusion injury, resulting in the inhibition of proinflammatory activity. | Glycine | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |
| 3 | The activation of AKT mediates the inhibition of NF-kappaB p65/Hif-1alpha signaling by glycine. | Glycine | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |
| 4 | Taken together, our findings provide a new understanding of glycine in neuroprotection by inhibiting M1 microglial polarization and promoting anti-inflammation by suppressing NF-kappaB p65/Hif-1alpha signaling. | Glycine | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |