Pub. Date : 2019 Feb
PMID : 30709876
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Refractory and metastatic infantile fibrosarcoma harboring LMNA-NTRK1 fusion shows complete and durable response to crizotinib. | Crizotinib | neurotrophic receptor tyrosine kinase 1 | Homo sapiens |
| 2 | In this report, we outline the use of integrative clinical sequencing (ICS) including RNA-seq in a patient with refractory, metastatic IFS to reveal an unusual fusion (LMNA-NTRK1), not detected by routine FISH testing, which was treated with oral crizotinib and resulted in a complete and durable long-term response. | Crizotinib | neurotrophic receptor tyrosine kinase 1 | Homo sapiens |