Pub. Date : 2019 Jul
PMID : 30707970
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Soy isoflavones reduce asthma exacerbation in asthmatic patients with high PAI-1-producing genotypes. | Isoflavones | serpin family E member 1 | Homo sapiens |
| 2 | Previous studies suggest that soy isoflavones can reduce PAI-1 levels. | Isoflavones | serpin family E member 1 | Homo sapiens |
| 3 | OBJECTIVE: We sought to investigate PAI-1 genotype-specific differences of the soy isoflavone response in asthma outcomes. | Isoflavones | serpin family E member 1 | Homo sapiens |
| 4 | METHODS: A PAI-1 functional polymorphism (rs1799768, 4G5G) was characterized in subjects with poorly controlled asthma enrolled in a randomized clinical trial of soy isoflavones (n = 265). | Isoflavones | serpin family E member 1 | Homo sapiens |
| 5 | Soy isoflavones reduced plasma PAI-1 levels compared with placebo. | Isoflavones | serpin family E member 1 | Homo sapiens |
| 6 | CONCLUSIONS: This study demonstrates that soy isoflavone treatment provides a significant benefit in reducing the number of severe asthma exacerbations in asthmatic patients with the high PAI-1-producing genotype. | Isoflavones | serpin family E member 1 | Homo sapiens |
| 7 | PAI-1 polymorphisms can be used as a genetic biomarker for soy isoflavone-responsive patients with asthma. | Isoflavones | serpin family E member 1 | Homo sapiens |