Pub. Date : 2019 Mar
PMID : 30691847
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We determined the dual neuroprotective-neurotoxic effects of sevoflurane postconditioning after HSR injury using a model of blood loss and reinfusion in rats via the heme oxygenase-1 (HO-1)/reactive oxygen species (ROS) signal pathway. | Sevoflurane | heme oxygenase 1 | Rattus norvegicus |
| 2 | RESULTS: Compared with HSR alone, 2% sevoflurane postconditioning improved latency and increased MMP levels, HO-1 expression, and HO activity but decreased TdT-mediated dUTP nick-end labeling-positive cells, cleaved caspase-3 (17 kDa) expression, and ROS production. | Sevoflurane | heme oxygenase 1 | Rattus norvegicus |
| 3 | CONCLUSION: The dual neuroprotective-neurotoxic effects of 2%-4% sevoflurane postconditioning after HSR injury might be associated with increased ROS via the "threshold effect" of HO-1. | Sevoflurane | heme oxygenase 1 | Rattus norvegicus |